7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine
AR7
CAS: 80306-38-3
Molecular Formula: C15H12ClNO
7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine - Names and Identifiers
7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine - Physico-chemical Properties
| Molecular Formula | C15H12ClNO |
| Molar Mass | 257.71 |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Sealed in dry,2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| In vitro study | Treatment with RARA antagonist, AR7 (20 μM; for 16 h), increased lysosomal activity in WT and LRRK2 R1441G KI mutant MEFs. Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA. |
7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.88 ml | 19.401 ml | 38.803 ml |
| 5 mM | 0.776 ml | 3.88 ml | 7.761 ml |
| 10 mM | 0.388 ml | 1.94 ml | 3.88 ml |
| 5 mM | 0.078 ml | 0.388 ml | 0.776 ml |
Last Update：2024-01-02 23:10:35
7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine - Reference Information
| use | ar7 is a CMA booster for biological research on the chemical regulation of retinoic acid derivative-mediated partner cell autophagy. |
| Biological activity | AR7 is a retinoic acid receptor α(RARα) antagonist. |
| Target | RARα |
| in vitro study | Treatment with RARA antagonist, AR7 (20 μM; For 16 h), increased lysosomal activity in WT and LRRK2 R1441G KI utantmefs. Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity Occurring and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA. |
Last Update：2024-04-09 20:52:54
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Product Name: AR7 Visit Supplier Webpage Request for quotationCAS: 80306-38-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: AR7 Visit Supplier Webpage Request for quotationCAS: 80306-38-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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